Senegal enjoys an excellent relationship with the United States. The Government of Senegal is known and respected for its able diplomats and has often supported the U.S. in the United Nations, including with troop contributions for peacekeeping activities. The United States maintains friendly relations with Senegal and provides considerable economic and technical assistance. About 300 Senegalese students come to the United States each year for study.

President Diouf paid his first official visit to Washington, DC, in August 1983 and traveled several times to the U.S. thereafter. Senegal was President George W. Bush's first stop in his July 2003 visit to Africa. In June 2001, President Wade met President Bush at the White House. Senegal hosted the Second African-African American Summit in 1995. First Lady Hillary Rodham Clinton began her trip to Africa in March 1997 with a visit to Senegal, and President Bill Clinton visited Senegal in 1998. Assistant Secretary for African Affairs Walter Kansteiner visited Senegal in August 2001. Foreign Minister Gadio met Secretary of State Colin Powell in September and November 2001.

Senegal took a strong position against terrorism in the wake of the September 11, 2001 terrorist attacks against the U.S., and in October 2001 hosted a conference establishing the African Pact Against Terrorism. On July 20, 2005, Secretary Rice attended the fourth annual African Growth and Opportunity Act (AGOA) Forum held in Dakar, Senegal. That year's Forum focused on increasing investment initiatives and facilitating economic and political development in Africa. In June 2007, First Lady Laura Bush made Senegal her first stop during a four country Africa tour in support of the President's Malaria Initiative (PMI) and the President Emergency Plan for AIDS Relief (PEPFAR) (Senegal(02/08)).